The Change Of Occludin Expression In The Injury Of The Blood- Brain Barrier Of Rats Induced By Microwave Exposure

With the extensive application of microwave technology and the arriving information era, microwave biological effects and mechanism become the topics at the forefront of bioelectromagnetics. Blood-brain barrier (BBB) in the maintenance of environmental stability of the brain plays an important role in the process, its function is based on the structure of the brain capillary endothelial cells and their intercellular tight junction (TJ). Occludin is directly involved in the TJ formation, which as a kind of key TJ proteins, and plays an important role for the maintenance of BBB permeability, its expression changes may be directly results in the BBB dysfunction, thereby affecting the balance of the brain environment. The research aims to explore the rule of occludin expression changes in rat hippocampus after a long-term low doses of microwave exposure, in order to identify the mechanism of occludin in the microwave exposure-induced brain injury.